Burguière, E., Arleo A., Hojjati, M.R., Elgersma, Y., De Zeeuw, C.I., Bethoz, A. and Rondi-Reig, L. Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?. Nature Neuroscience, 2005. (to appear)

Sony CSL authors: Angelo Arleo

Abstract

L7-PKCI transgenic mice, which lack parallel fiber−Purkinje cell long-term depression (LTD), were tested with two different mazes to dissociate the relative importance of declarative and procedural components of spatial navigation. We show that L7-PKCI mice are deficient in acquisition of an adapted goal-oriented behavior, part of the procedural component of the task. This supports the hypothesis that cerebellar LTD may subserve a general sensorimotor adaptation process shared by motor and spatial learning functions.

BibTeX entry

@ARTICLE { burguiere:05a, AUTHOR="Burguière, E. and Arleo A. and Hojjati, M.R. and Elgersma, Y. and De Zeeuw, C.I. and Bethoz, A. and Rondi-Reig, L.", JOURNAL="Nature Neuroscience", NOTE="(to appear)", TITLE="Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?", YEAR="2005", }