A strong reading comprehension ability is not only one of the cornerstones of a successful education but also a crucial skill for various aspects of our daily lives, both in the workplace and personal life. Nonetheless, text comprehension is a fascinating and complex cognitive tasks since it requires motivation, attention, memory, as well as specific language skills, which can prove challenging and frustrating for many children with learning disabilities or some language learners. In this talk, we introduce an Natural Language Processing (NLP)-powered reading comprehension framework to explore the potential of some NLP techniques in hybrid therapeutic practices, aiming to make the rehabilitation of text comprehension difficulties more accessible, multi-modal, and truly inclusive for students with special educational needs and disabilities, in presence or at a distance.