Information theory, probability and statistical dependencies, and algebraic topology provide different views of a unified theory yet currently in development, where uncertainty goes as deep as Galois’s ambiguity theory, topos and motivs. I will review some foundations led notably by Bennequin and Vigneaux, that characterize uniquely entropy as the first group of cohomology, on random variable complexes and probability laws. This framework allows to retrieve most of the usual information functions, like KL divergence, cross entropy, Tsallis entropies, differential entropy in different generality settings. Multivariate interaction/Mutual information (I_k and J_k) appear as coboundaries, and their negative minima, also called synergy, corresponds to homotopical link configurations, which at the image of Borromean links, illustrate what purely collective interactions or emergence can be. Those functions refine and characterize statistical independence in the multivariate case, in the sens that (X1,…,Xn) are independent iff all the I_k=0 (with 1